Beilstein J. Org. Chem.2014,10, 1372–1382, doi:10.3762/bjoc.10.140
conformation is related to the folding of helical polyglycineII (PG II). Tri- and tetraantennary molecules are capable of association if the antenna length reach 7 glycine (Gly) residues. Properties of similar biantennary molecules have not been investigated yet, and we compared their self-aggregating potency
assembling glycopeptides demonstrated an antiviral potency which was up to 50 times higher than the activity of peptide-free glycans.
Keywords: glycopeptides; influenza virus; multivalent glycosystems; oligoglycine; polyglycineII; self-assembling; tectomers; Introduction
Recently, we have synthesized and
called tectomers. Tectomers in a layer are packed by polyglycineII type (PG II) [4][5]. Their helical polypeptide chain fundamentally differs from the canonical α-helix. The association of symmetrical tetra- and triantennary (star-like) oligoglycines spontaneously proceeds only when the number of
PDF
Graphical Abstract
Figure 1:
The structure of biantennary oligoglycines and their glyco derivatives (sp = spacer group).